A stiff blow from the stroma: collagen crosslinking drives tumor progression

Cancer Cell. 2009 Dec 8;16(6):455-7. doi: 10.1016/j.ccr.2009.11.013.


Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.

MeSH terms

  • Collagen / metabolism*
  • Disease Progression
  • Focal Adhesion Protein-Tyrosine Kinases / metabolism
  • Humans
  • Neoplasm Invasiveness
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Phosphorylation
  • Protein-Lysine 6-Oxidase / metabolism


  • Collagen
  • Protein-Lysine 6-Oxidase
  • Focal Adhesion Protein-Tyrosine Kinases