Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009;2009:2715-8.
doi: 10.1109/IEMBS.2009.5333389.

In Vivo Diffusion Tensor Imaging of Chronic Spinal Cord Compression in Rat Model

Affiliations

In Vivo Diffusion Tensor Imaging of Chronic Spinal Cord Compression in Rat Model

Matthew M Cheung et al. Conf Proc IEEE Eng Med Biol Soc. .

Abstract

Chronic spinal cord compression induced cervical myelopathy is a comon cause of spinal cord dysfunction. The exact mechanisms of underlying progressive cell death remain to be elucidated. In this study, in vivo diffusion tensor imaging (DTI) has been applied to investigate the microstructural changes of white matter (WM) in this neurodegenerative disease. Compared with conventional MRI techniques, DTI is believed to be more specific to pathological changes. Radial diffusivity (lambda upper left and right quadrants) is higher in the ipilesional region, suggesting demyelination or axonal degradation may occur after prolonged compression. Near the epicenter of lesion, axial diffusivity (lambda(//)) is lower. Also, caudal-rostral asymmetry has been observed in lambda(//). Feasibility of using DTI to detect microstructural changes in chronic disease has been demonstrated.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback