fpr, a deficient Xer recombination site from a Salmonella plasmid, fails to confer stability by dimer resolution: comparative studies with the pJHCMW1 mwr site

J Bacteriol. 2010 Feb;192(3):883-7. doi: 10.1128/JB.01082-09. Epub 2009 Dec 4.


Salmonella plasmid pFPTB1 includes a Tn3-like transposon and a Xer recombination site, fpr, which mediates site-specific recombination at efficiencies lower than those required for stabilizing a plasmid by dimer resolution. Mutagenesis and comparative studies with mwr, a site closely related to fpr, indicate that there is an interdependence of the sequences in the XerC binding region and the central region in Xer site-specific recombination sites.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Models, Biological
  • Molecular Sequence Data
  • Plasmids / chemistry
  • Plasmids / genetics*
  • Salmonella / genetics*
  • Sequence Homology, Amino Acid