Hypoglycemic action of chicken meat extract in type-2 diabetic KKAy mice and GK rats

Biosci Biotechnol Biochem. 2009 Dec;73(12):2583-8. doi: 10.1271/bbb.90328. Epub 2009 Dec 7.


This study researched the effects of chicken meat extract on blood glucose and insulin level, membrane glucose transporter-4 (GLUT4), and tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) in type 2 diabetic KKAy mice and GK rats. Eight-week-old KKAy mice and GK rats and euglycemic control animals, C57BL/6J mice and Wistar rats, were orally administered a liquid commercial chicken meat extract, BRAND'S Essence of Chicken (BEC), for up to 8 weeks. BEC (1.5 ml/kg) had no effect on blood insulin levels, but significantly lessened the hyperglycemia in the diabetic animals. In the BEC-treated diabetic animals, insulin induced a significant increase in plasma membrane GLUT4 and cytosolic tyrosine-phosphorylated IRS-1, indicating that it attenuates insulin resistance. The present findings are the first demonstration of the hypoglycemic action of a dietary protein, and they lend credence to the reported benefits of using chicken meat as a source of protein in the dietary management of diabetic individuals.

MeSH terms

  • Animals
  • Blood Glucose / metabolism*
  • Chickens*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Dietary Proteins / pharmacology*
  • Glucose Tolerance Test
  • Hyperglycemia / complications
  • Hyperglycemia / diet therapy*
  • Insulin / blood
  • Insulin Resistance
  • Male
  • Meat*
  • Mice
  • Phosphorylation / drug effects
  • Rats
  • Tyrosine / metabolism


  • Blood Glucose
  • Dietary Proteins
  • Insulin
  • Tyrosine