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. 2009;5:597-610.
doi: 10.2147/ndt.s5212. Epub 2009 Nov 16.

Coenzyme Q10 Effects in Neurodegenerative Disease

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Free PMC article

Coenzyme Q10 Effects in Neurodegenerative Disease

Meredith Spindler et al. Neuropsychiatr Dis Treat. .
Free PMC article

Abstract

Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress. Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson's disease and atypical Parkinson's syndromes, Huntington's disease, Alzheimer disease, Friedreich's ataxia, and amyotrophic lateral sclerosis, with equivocal findings. CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.

Keywords: Huntington’s disease; Parkinson’s disease; coenzyme Q10; mitochondrial dysfunction; neurodegenerative disease.

Figures

Figure 1
Figure 1
Chemical structures of Coenzyme Q10 and its short-chain analog, idebenone.
Figure 2
Figure 2
CoQ10 in the mitochondrial electron transport chain. Coenzyme Q10 is a component of the electron transport chain located within the inner mitochondrial membrane, required for oxidative phosphorylation leading to ATP generation. It accepts electrons from complexes I(NADH-ubiquinone oxidoreductase) and II (succinate dehydrogenase) for transfer to complex III (ubiquinol-cytochrome c reductase). Idebenone is similarly involved in transfer of electrons from complex I to complex III.

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