Generalization of the effects of phonological training for anomia using structural equation modelling: a multiple single-case study

Neurocase. 2010 Apr;16(2):93-105. doi: 10.1080/13554790903329117. Epub 2009 Dec 4.


Structural Equation Modelling analysis of three longitudinal er-fMRI sessions was used to test the impact of phonological training and of the generalization process on the pattern of brain connectivity during overt picture naming in two chronic anomic patients. Phonological training yielded a positive effect on the trained material. Six months after the training, a generalization of the positive impact on the untrained items was also observed. Connectivity analysis showed that training and generalization effects shared paralleled cortical patterns of functional integration. These findings may represent the neurophysiological correlate of the training-induced cognitive strategies for the compensation of anomia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anomia / physiopathology*
  • Anomia / therapy*
  • Aphasia / physiopathology
  • Aphasia / rehabilitation
  • Brain / physiopathology*
  • Brain Injuries / complications
  • Computer Simulation
  • Humans
  • Language
  • Language Therapy / methods*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Models, Neurological
  • Nerve Net / physiopathology
  • Neural Pathways / physiopathology
  • Outcome Assessment, Health Care
  • Phonetics*
  • Speech / physiology
  • Stroke / complications
  • Teaching / methods*
  • Treatment Outcome
  • Verbal Behavior / physiology
  • Young Adult