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. 2010 Jan 13;132(1):275-80.
doi: 10.1021/ja906996c.

Enantioselective Synthesis of (+)-Cephalostatin 1

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Enantioselective Synthesis of (+)-Cephalostatin 1

Kevin C Fortner et al. J Am Chem Soc. .

Abstract

This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C-H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.

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