Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity

FEBS Lett. 2010 Feb 5;584(3):493-9. doi: 10.1016/j.febslet.2009.11.096. Epub 2009 Dec 4.


Immune cells navigate through different environments where they experience different mechanical forces. Responses to external forces are determined by the mechanical properties of a cell and they depend to a large extent on the actin-rich cell cortex. We report here that Myo1G, a previously uncharacterised member of class I myosins, is expressed specifically in haematopoietic tissues and cells. It is associated with the plasma membrane. This association is dependent on a conserved PH-domain-like myosin I tail homology motif and the head domain. However, the head domain does not need to be a functional motor. Knockdown of Myo1G in Jurkat cells decreased cell elasticity significantly. We propose that Myo1G regulates cell elasticity by deformations of the actin network at the cell cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / metabolism
  • Animals
  • Cell Line
  • Cell Line, Tumor
  • Cell Membrane / metabolism*
  • Elasticity / physiology*
  • Hematopoiesis / genetics
  • Hematopoiesis / physiology*
  • In Vitro Techniques
  • Lymph Nodes / metabolism
  • Mice
  • Microscopy, Atomic Force
  • Microscopy, Fluorescence
  • Myosins / genetics
  • Myosins / metabolism
  • Myosins / physiology*
  • RNA, Small Interfering
  • Spleen / metabolism
  • Thymus Gland / metabolism


  • Actins
  • RNA, Small Interfering
  • Myosins