Amyloid fibril formation in the rough endoplasmic reticulum of plasma cells from a patient with localized A lambda amyloidosis

Lab Invest. 1991 Feb;64(2):265-71.


Evidence for amyloid fibril formation in rough endoplasmic reticulum (RER) of plasma cells from the duodenum of a 62-year-old man with localized A lambda amyloidosis is described. The inclusions in RER of plasma cells were composed of tightly packed, regular arrays of fibrils cut in both longitudinal and cross-sections. The fibrils within the inclusions, measuring 10 nm in width, were oriented parallel to the long axis of the inclusions. By immunoelectron microscopy with an antihuman A lambda antiserum, gold particles labeled the fibrils located both in the RER of plasma cells and in the extracellular space. In addition, electron-dense material in the dilated RER was occasionally labeled. These findings suggest that at least some amyloid fibrils are unequivocally created in the RER of plasma cells.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / metabolism
  • Amyloid / ultrastructure*
  • Amyloidosis / pathology*
  • Bone Marrow / pathology
  • Duodenum / pathology
  • Endoplasmic Reticulum / ultrastructure*
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Microscopy, Immunoelectron
  • Middle Aged
  • Plasma Cells / pathology
  • Plasma Cells / ultrastructure*
  • Rectum / pathology
  • Skin / pathology
  • Stomach / pathology


  • Amyloid