Dysplasia and DNA aneuploidy in a pelvic pouch. Report of a case

Dis Colon Rectum. 1991 Mar;34(3):280-3; discussion 283-4. doi: 10.1007/BF02090171.

Abstract

A patient with an 18-year history of ulcerative colitis was operated on with colectomy, mucosal proctectomy, ileoanal anastomosis, and an S-type pelvic pouch due to intractable chronic continuous disease. The patient was followed by endoscopic controls and biopsy sampling from the pouch at regular intervals. A gradual development of severe atrophy in the ileal mucosa was followed by the development of low grade dysplasia. At the most recent endoscopic control, 4 years after the construction of the pouch, biopsies were sampled also for flow cytometric DNA analyses. DNA aneuploidy was detected in a biopsy from the center of the pouch, and a biopsy taken immediately adjacent showed low grade dysplasia. These findings underline the importance of endoscopic follow-up after construction of a pelvic pouch and focus attention to the potential of malignant transformation of the mucosa.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anal Canal / pathology*
  • Anal Canal / surgery
  • Anastomosis, Surgical
  • Aneuploidy*
  • Atrophy
  • Biopsy
  • Colectomy
  • Colitis, Ulcerative / genetics
  • Colitis, Ulcerative / pathology
  • Colitis, Ulcerative / surgery
  • DNA / genetics*
  • Humans
  • Ileum / pathology*
  • Ileum / surgery
  • Intestinal Mucosa / pathology*
  • Male
  • Precancerous Conditions / genetics
  • Precancerous Conditions / pathology*
  • Rectum / surgery

Substances

  • DNA