Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population

Hum Genet. 1991 Feb;86(4):369-70. doi: 10.1007/BF00201836.


We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Colonic Neoplasms / genetics*
  • Gene Frequency
  • Genetic Carrier Screening
  • Humans
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Rectal Neoplasms / genetics*
  • Reference Values
  • Tumor Suppressor Protein p53 / genetics*


  • Oligonucleotide Probes
  • Tumor Suppressor Protein p53