[Anticonvulsants as bioantioxidants under stress conditions]

G N Bogdanov; D V Mishchenko; R A Kotel'nikova; E S Frog; I I Faĭngol'd; L V Tat'ianenko; O V Dorokhotova; Ia R Nartsissov

[Anticonvulsants as bioantioxidants under stress conditions]

Biomed Khim. 2009 Jul-Aug;55(4):519-24.

[Article in Russian]

Authors

G N Bogdanov, D V Mishchenko, R A Kotel'nikova, E S Frog, I I Faĭngol'd, L V Tat'ianenko, O V Dorokhotova, Ia R Nartsissov

PMID: 20000129

Abstract

The action of heterocyclic amides series (ethosuximide, phenytoin, primidone) on lipid peroxidation and membrane bound monoamine oxidases A and B under stress condition has been studied. The intraperitoneal injection of the drugs resulted in enhancement of SOD, decrease of brain malondialdehyde content and mitochondrial activity of monoamine oxidases A and B.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticonvulsants / pharmacology*
Antioxidants / pharmacology*
Brain / metabolism
Ethosuximide / pharmacology
Lipid Peroxidation / drug effects
Membrane Lipids / metabolism
Mitochondria / drug effects
Mitochondria / metabolism
Monoamine Oxidase / metabolism
Phenytoin / pharmacology
Primidone / pharmacology
Rats
Rats, Wistar
Stress, Psychological / metabolism*
Superoxide Dismutase / metabolism

Substances

Anticonvulsants
Antioxidants
Membrane Lipids
Primidone
Ethosuximide
Phenytoin
Superoxide Dismutase
Monoamine Oxidase