Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer

J Med Chem. 2010 Mar 25;53(6):2333-44. doi: 10.1021/jm901090b.

Author

Andrew P Combs¹

Affiliation

¹ Incyte Corporation, Experimental Station, E336/131A, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA. acombs@incyte.com

PMID: 20000419
DOI: 10.1021/jm901090b

No abstract available

MeSH terms

Crystallography, X-Ray
Diabetes Mellitus / drug therapy*
Diabetes Mellitus / enzymology
Drug Discovery / methods
Drug Discovery / trends
Drug Industry / methods
Drug Industry / trends
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
Enzyme Inhibitors / therapeutic use
Humans
Models, Molecular
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / enzymology
Obesity / drug therapy*
Obesity / enzymology
Protein Structure, Tertiary
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / chemistry

Substances

Enzyme Inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1