Palladium-catalyzed decarboxylative benzylation of diphenylglycinate imines

Org Lett. 2010 Jan 15;12(2):316-9. doi: 10.1021/ol902651j.

Abstract

General reaction conditions for the Pd-catalyzed decarboxylative benzylation of benzyl diphenylglycinate imines are described. The overall procedure requires a simple catalyst/ligand combination to form a new Csp(3)-Csp(3) bond. Microwave irradiation greatly accelerated the transformation. Moreover, various heteroaromatic moieties are tolerated in both the imine and ester components.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Decarboxylation
  • Glycine / analogs & derivatives
  • Glycine / chemistry*
  • Imines / chemical synthesis*
  • Imines / chemistry*
  • Microwaves
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Palladium / chemistry*

Substances

  • Imines
  • Organometallic Compounds
  • Palladium
  • Glycine