Molecular mechanisms of metabolic regulation by insulin in Drosophila

Biochem J. 2009 Dec 14;425(1):13-26. doi: 10.1042/BJ20091181.


The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and longevity. In the present review, I discuss the molecular mechanisms by which insulin signalling regulates metabolism in Drosophila, comparing and contrasting with the mammalian system. I discuss both the intracellular signalling network, as well as the communication between organs in the fly.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila / genetics
  • Drosophila / metabolism
  • Drosophila / physiology*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Insulin / metabolism*
  • Insulin Receptor Substrate Proteins / metabolism
  • Models, Biological
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphorylation
  • Receptor, Insulin / genetics
  • Receptor, Insulin / metabolism*
  • Signal Transduction / physiology*


  • Drosophila Proteins
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Phosphatidylinositol 3-Kinases
  • Receptor, Insulin