Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injury

Wound Repair Regen. Jan-Feb 2010;18(1):89-97. doi: 10.1111/j.1524-475X.2009.00550.x. Epub 2009 Dec 11.


The vocal fold mucosa plays an important role in voice production. Its cellular composition and density frequently change under various pathological conditions, often contributing to altered extracellular matrix production, tissue viscoelasticity, and voice quality. In this study, cellular changes in the rat mucosa following a unilateral stripping injury were investigated and analyzed semi-quantitatively. Distinctive and sequential changes in cellular morphology, composition, and density were observed in the mucosa post-injury. Cellular recruitment was a major event during the early stage of injury and reached its peak level by day 5 post-injury. Several types of cells, including neutrophil-like cells, epithelial cells, and fibroblast-like cells, were sequentially recruited. The sequential emergence of reactive cell populations following injury and subsequent reconstruction of the mucosa suggests their involvement in vocal fold tissue repair and scar formation processes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Laryngeal Mucosa / pathology*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Vocal Cords / injuries*
  • Vocal Cords / pathology*