Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix) injections versus local anesthetic in osteoarthritis of the hip

Arthritis Res Ther. 2009;11(6):R183. doi: 10.1186/ar2875. Epub 2009 Dec 9.


Introduction: Comparison of intra-articular bacterial-derived hyaluronic acid (Hyalubrix) (HA) with local analgesia (mepivacaine) for osteoarthritis (OA) of the hip.

Methods: A pilot prospective, double-blind, 6-month randomized trial of 42 patients with hip OA. HA or mepivacaine was administered twice (once a month) under ultrasound guidance. Efficacy measurements included the Lequesne's algofunctional index, a visual analog scale for pain, concomitant use of analgesia, patient and physician global measurement, and safety.

Results: Patients in the HA group exhibited a significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment (P < 0.001) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment (P < 0.05) compared with the local anesthetic group. All primary and secondary measures were significantly improved versus baseline, but other than the above were not different from each other at 3 or 6 months. Adverse effects were minimal.

Conclusions: This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA.

Trial registration number: ISRCTN39397064.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anesthetics, Local / administration & dosage*
  • Anesthetics, Local / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / adverse effects
  • Injections, Intra-Articular
  • Male
  • Mepivacaine / administration & dosage*
  • Mepivacaine / adverse effects
  • Middle Aged
  • Osteoarthritis, Hip / complications
  • Osteoarthritis, Hip / drug therapy*
  • Pain / drug therapy
  • Pain / etiology
  • Pain Measurement
  • Pilot Projects
  • Viscosupplements / administration & dosage*
  • Viscosupplements / adverse effects


  • Anesthetics, Local
  • Viscosupplements
  • Hyaluronic Acid
  • Mepivacaine

Associated data

  • ISRCTN/ISRCTN39397064