Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndrome

Diabetes Res Clin Pract. 2010 Feb;87(2):261-6. doi: 10.1016/j.diabres.2009.11.003. Epub 2009 Dec 8.


Aims: The mechanism for the association between diabetes and hypomagnesaemia remains uncertain. This study aimed to test whether hypomagnesaemia is present in pre-diabetes, obesity and the metabolic syndrome.

Methods: 1453 adults from randomly selected households from rural Victoria, Australia, attended for biomedical assessment. Serum magnesium concentrations, hypomagnesaemia defined using local laboratory criteria (<0.70mmol/l), and defined by the bottom quintile of serum magnesium concentrations, were compared in different diabetes pre-cursor states including metabolic syndrome using ATP III criteria.

Results: The mean serum magnesium was 0.84+/-0.06mmol/l and 25 (1.7%) had a low magnesium. Mean magnesium was lower among those with known diabetes than those with new diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and normal subjects (0.79 (0.78-0.81) vs 0.83 (0.81-0.86); 0.84 (0.82-0.85); 0.84 (0.82-0.86); 0.85 (0.84-0.85)mmol/l). After adjusting for confounders, and compared with those without diabetes, hypomagnesaemia was 10.51 (1.37-80.60)-fold more common with new diabetes, 8.63 (2.20-33.90)-fold more common with known diabetes, 6.77 (1.75-26.17)-fold more common among those taking anti-hypertensive medication but with no difference to those with IGT/IFG (0.90 (0.10-8.10)).

Conclusion: Diabetes is associated with hypomagnesaemia, but not its pre-cursor states.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Australia
  • Creatinine / blood
  • Diabetes Mellitus / blood*
  • Diabetes Mellitus / epidemiology*
  • Female
  • Health Status
  • Humans
  • Magnesium / blood*
  • Magnesium Deficiency / complications*
  • Magnesium Deficiency / epidemiology*
  • Male
  • Metabolic Syndrome / blood
  • Middle Aged
  • Obesity / blood
  • Prediabetic State / blood
  • Surveys and Questionnaires
  • Uric Acid / blood


  • Uric Acid
  • Creatinine
  • Magnesium