Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium

Marie Petitbarat; Valérie Serazin; Sylvie Dubanchet; Robert Wayner; Philippe de Mazancourt; Gérard Chaouat; Nathalie Lédée

doi:10.1016/j.fertnstert.2009.10.049

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium

Fertil Steril. 2010 Aug;94(3):1141-3. doi: 10.1016/j.fertnstert.2009.10.049. Epub 2009 Dec 11.

Authors

Marie Petitbarat¹, Valérie Serazin, Sylvie Dubanchet, Robert Wayner, Philippe de Mazancourt, Gérard Chaouat, Nathalie Lédée

Affiliation

¹ INSERM, U 782, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Université Paris-Sud, UMR-S0782, and Hôpital Antoine Béclère, Clamart, France.

PMID: 20004376
DOI: 10.1016/j.fertnstert.2009.10.049

Abstract

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) could play a role in the regulation of interleukin (IL)-15 and IL-18, cytokines crucial for angiogenesis and uterine natural killer (uNK) cell recruitment during embryo implantation. We therefore confirmed the endometrial presence of TWEAK/fibroblast growth factor inducible-14 (Fn-14) and documented simultaneously the cytotoxic KIR receptor (NKp46) of uNK cells in the human endometrium while TWEAK, Fn-14, IL-15, and IL-18 mRNA were quantified by real-time polymerase chain reaction in relation to the recruitment of CD56+ cells among fertile control women and patients who had failed to implant after assisted reproduction treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Cell Count
Cytokine TWEAK
Endometrium / drug effects
Endometrium / immunology
Endometrium / metabolism*
Endometrium / pathology
Female
Gene Expression Regulation
Humans
Infertility, Female / genetics
Infertility, Female / metabolism
Infertility, Female / pathology
Interleukin-15 / genetics*
Interleukin-15 / metabolism
Interleukin-15 / pharmacology
Interleukin-18 / genetics*
Interleukin-18 / metabolism
Interleukin-18 / pharmacology
Killer Cells, Natural / cytology
Killer Cells, Natural / metabolism
Pregnancy
Receptors, Tumor Necrosis Factor / genetics
Receptors, Tumor Necrosis Factor / metabolism
Receptors, Tumor Necrosis Factor / physiology*
TWEAK Receptor
Tumor Necrosis Factors / genetics
Tumor Necrosis Factors / metabolism
Tumor Necrosis Factors / physiology*

Substances

Cytokine TWEAK
Interleukin-15
Interleukin-18
Receptors, Tumor Necrosis Factor
TNFRSF12A protein, human
TNFSF12 protein, human
TWEAK Receptor
Tumor Necrosis Factors