Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium

Fertil Steril. 2010 Aug;94(3):1141-3. doi: 10.1016/j.fertnstert.2009.10.049. Epub 2009 Dec 11.

Abstract

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) could play a role in the regulation of interleukin (IL)-15 and IL-18, cytokines crucial for angiogenesis and uterine natural killer (uNK) cell recruitment during embryo implantation. We therefore confirmed the endometrial presence of TWEAK/fibroblast growth factor inducible-14 (Fn-14) and documented simultaneously the cytotoxic KIR receptor (NKp46) of uNK cells in the human endometrium while TWEAK, Fn-14, IL-15, and IL-18 mRNA were quantified by real-time polymerase chain reaction in relation to the recruitment of CD56+ cells among fertile control women and patients who had failed to implant after assisted reproduction treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cell Count
  • Cytokine TWEAK
  • Endometrium / drug effects
  • Endometrium / immunology
  • Endometrium / metabolism*
  • Endometrium / pathology
  • Female
  • Gene Expression Regulation
  • Humans
  • Infertility, Female / genetics
  • Infertility, Female / metabolism
  • Infertility, Female / pathology
  • Interleukin-15 / genetics*
  • Interleukin-15 / metabolism
  • Interleukin-15 / pharmacology
  • Interleukin-18 / genetics*
  • Interleukin-18 / metabolism
  • Interleukin-18 / pharmacology
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / metabolism
  • Pregnancy
  • Receptors, Tumor Necrosis Factor / genetics
  • Receptors, Tumor Necrosis Factor / metabolism
  • Receptors, Tumor Necrosis Factor / physiology*
  • TWEAK Receptor
  • Tumor Necrosis Factors / genetics
  • Tumor Necrosis Factors / metabolism
  • Tumor Necrosis Factors / physiology*

Substances

  • Cytokine TWEAK
  • Interleukin-15
  • Interleukin-18
  • Receptors, Tumor Necrosis Factor
  • TNFRSF12A protein, human
  • TNFSF12 protein, human
  • TWEAK Receptor
  • Tumor Necrosis Factors