Antitubercular potential of some semisynthetic analogues of phytol

Dharmendra Saikia; Swati Parihar; D Chanda; S Ojha; J K Kumar; C S Chanotiya; K Shanker; Arvind S Negi

doi:10.1016/j.bmcl.2009.11.107

Antitubercular potential of some semisynthetic analogues of phytol

Bioorg Med Chem Lett. 2010 Jan 15;20(2):508-12. doi: 10.1016/j.bmcl.2009.11.107. Epub 2009 Nov 26.

Authors

Dharmendra Saikia¹, Swati Parihar, D Chanda, S Ojha, J K Kumar, C S Chanotiya, K Shanker, Arvind S Negi

Affiliation

¹ Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, PO CIMAP, Lucknow 226 015, UP, India.

PMID: 20004575
DOI: 10.1016/j.bmcl.2009.11.107

Abstract

Phytol, a diterpene alcohol was modified to several semisynthetic analogues. Some of the modifications were done logically to enhance lipophilicity of the molecule. Analogues 14, 16 and 18 exhibited antitubercular activity (MIC 15.6-50microg/mL) better than phytol (100microg/mL). The most potent analogue 18 was evaluated for in vivo toxicity in Swiss albino mice and was well tolerated by the experimental animals up to 300mg/kg body weight as a single oral acute dose.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / toxicity
Mice
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Oximes / chemical synthesis*
Oximes / chemistry
Oximes / toxicity
Phytol / analogs & derivatives*
Phytol / chemical synthesis
Phytol / chemistry
Phytol / toxicity

Substances

Antitubercular Agents
Oximes
Phytol