The treatment of HIV-associated nephropathy

Adv Chronic Kidney Dis. 2010 Jan;17(1):59-71. doi: 10.1053/j.ackd.2009.08.013.


Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is associated in part with suppression of HIV-1 viral replication. The extent to which the response to ART differs in persons with HIVAN compared with those with other HIV-associated kidney disorders is unknown. Beneficial effects of corticosteroids and angiotensin-converting enzyme inhibitors on kidney function also are suggested by retrospective cohort studies and uncontrolled trials of patients with HIVAN. Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • AIDS-Associated Nephropathy / drug therapy*
  • Adrenal Cortex Hormones / therapeutic use*
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Anti-Retroviral Agents / therapeutic use*
  • Humans
  • Kidney / drug effects


  • Adrenal Cortex Hormones
  • Angiotensin-Converting Enzyme Inhibitors
  • Anti-Retroviral Agents