Maternal and Neonatal Morbidities Associated With Obstructive Sleep Apnea Complicating Pregnancy

Am J Obstet Gynecol. 2010 Mar;202(3):261.e1-5. doi: 10.1016/j.ajog.2009.10.867. Epub 2009 Dec 14.


Objective: The objective of the study was to estimate the maternal and neonatal morbidities associated with obstructive sleep apnea (OSA) in pregnancy.

Study design: Women delivering between 2000-2008 with confirmed OSA in an academic center were included. Normal-weight and obese controls were randomly selected at a 2:1 ratio. Maternal and neonatal morbidities were compared between the groups. Multivariate analyses were performed to evaluate maternal morbidity and preterm birth (PTB).

Results: The analysis included 57 pregnancies complicated by OSA. Compared with normal-weight (n = 114) controls, OSA patients had more preeclampsia (PET) (19.3% vs 7.0%; P = .02) and PTB (29.8% vs 12.3%; P = .007). Controlling for comorbid conditions, OSA was associated with an increased risk of PTB (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.02-6.6), mostly secondary to PET (63%). Cesarean delivery (OR, 8.1; 95% CI, 2.9-22.1) and OSA were associated with maternal morbidity (OR, 4.6; 95% CI, 1.5-13.7).

Conclusion: Pregnancies complicated by OSA are at increased risk for preeclampsia, medical complications, and indicated PTB.

MeSH terms

  • Adult
  • Case-Control Studies
  • Cesarean Section / statistics & numerical data
  • Cohort Studies
  • Diabetes Mellitus / epidemiology
  • Female
  • Humans
  • Multivariate Analysis
  • Obesity / epidemiology
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Premature Birth / epidemiology*
  • Retrospective Studies
  • Sleep Apnea, Obstructive / epidemiology*