Prevalence of non-diabetic renal disease in patients with type 2 diabetes

Diabetes Res Clin Pract. 2010 Mar;87(3):354-9. doi: 10.1016/j.diabres.2009.11.012. Epub 2009 Dec 14.


It is important to differentiate proteinuria from non-diabetic renal diseases (NDRD) or diabetic nephropathy in diabetic patients. The purpose of our study was to evaluate the prevalence of NDRD. A retrospective analysis was performed on diabetic patients who had undergone renal biopsy during a 6-year period. Our study revealed a high prevalence of NDRD in the diabetic population. Sixty-nine patients were investigated, 52.2% were diagnosed as NDRD and 47.8% as DN. Focal segmental glomerulosclerosis was the most common lesion found in patients with NDRD. We found a relationship between DN and fasting blood glucose level, systolic blood pressure, diastolic blood pressure, LVMI, intima-media thickening (IMT), and the presence of carotid plaques. Patients with NDRD had a lower incidence of diabetic retinopathy (DR). The absence of DR to differentiate NDRD had a sensitivity of 72.7%, a specificity 91.7%, and an ROC=0.822. Fasting blood glucose level had a sensitivity and specificity of 93.9% and 75%, respectively. Similarly, the use of IMT had sensitivity and specificity of 90% and 75.8%, respectively. In this study, we determined that the absence of DR, a lower fasting blood glucose level, and IMT is useful in differentiating NDRD from DN in diabetic patients with overt proteinuria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Blood Glucose / metabolism
  • Chi-Square Distribution
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetic Nephropathies / diagnosis
  • Diabetic Nephropathies / epidemiology
  • Diagnosis, Differential
  • Echocardiography
  • Female
  • Humans
  • Kidney Diseases / complications*
  • Kidney Diseases / diagnosis
  • Kidney Diseases / epidemiology*
  • Male
  • Middle Aged
  • Prevalence
  • Proteinuria / diagnosis
  • Proteinuria / epidemiology
  • Proteinuria / etiology
  • ROC Curve
  • Regression Analysis
  • Retrospective Studies
  • Severity of Illness Index


  • Blood Glucose