Switching on epigenetic therapy

Cell. 2009 Dec 11;139(6):1029-31. doi: 10.1016/j.cell.2009.11.038.

Abstract

Reversible epigenetic changes that alter gene expression are a characteristic of many cancers and other diseases. Biotech companies are taking note and are starting to develop new drugs to reverse such pathogenic "epimutations."

MeSH terms

  • Chromatin Assembly and Disassembly / drug effects*
  • DNA Methylation
  • Epigenesis, Genetic*
  • Gene Expression Regulation
  • Histone Deacetylase Inhibitors / therapeutic use
  • Humans
  • Neoplasms / drug therapy*

Substances

  • Histone Deacetylase Inhibitors