Rab3 GTPase lands Bruchpilot

Neuron. 2009 Dec 10;64(5):595-7. doi: 10.1016/j.neuron.2009.11.029.

Abstract

Active zones are the sites of neurotransmitter release, but their assembly mechanisms are poorly understood. In this issue of Neuron, Graf et al. perform a genetic screen in Drosophila and uncover a novel role for the Rab3 GTPase in organizing the active zone at the neuromuscular junction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Calcium / metabolism
  • Drosophila
  • Drosophila Proteins / metabolism*
  • GTP Phosphohydrolases* / genetics
  • GTP Phosphohydrolases* / metabolism
  • Neuromuscular Junction / genetics
  • Neuromuscular Junction / metabolism
  • Neuromuscular Junction / ultrastructure
  • Presynaptic Terminals / metabolism*
  • Presynaptic Terminals / ultrastructure
  • Signal Transduction / physiology
  • rab3 GTP-Binding Proteins / metabolism*

Substances

  • BRP protein, Drosophila
  • Drosophila Proteins
  • GTP Phosphohydrolases
  • Rab3 protein, Drosophila
  • rab3 GTP-Binding Proteins
  • Calcium