Molecular Chaperones, Essential Partners of Steroid Hormone Receptors for Activity and Mobility

Biochim Biophys Acta. 2010 Jun;1803(6):641-9. doi: 10.1016/j.bbamcr.2009.11.012. Epub 2009 Dec 16.

Abstract

Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among different cellular compartments as they mature, are subjected to regulation and exert their biological functions. Understanding the processes governing the intracellular traffic of SHRs is important, since their unbalanced or erroneous localization could lead to the development of diseases. In this review, we not only explore the functions of the heat-shock protein 90 (Hsp90) molecular chaperone machine for the intracellular transport of SHRs, but also for the regulation of their nuclear mobility, for their recycling and for the regulation of their transcriptional output.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Fungi / metabolism
  • Gene Deletion
  • HSP90 Heat-Shock Proteins / metabolism
  • Humans
  • Ligands
  • Microtubules / metabolism
  • Models, Biological
  • Molecular Chaperones / metabolism*
  • Protein Binding
  • Protein Transport*
  • Receptors, Steroid / metabolism

Substances

  • HSP90 Heat-Shock Proteins
  • Ligands
  • Molecular Chaperones
  • Receptors, Steroid