Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 326 (5959), 1541-5

Mapping Human Genetic Diversity in Asia

HUGO Pan-Asian SNP ConsortiumMahmood Ameen AbdullaIkhlak AhmedAnunchai AssawamakinJong BhakSamir K BrahmachariGayvelline C CalacalAmit ChaurasiaChien-Hsiun ChenJieming ChenYuan-Tsong ChenJiayou ChuEva Maria C Cutiongco-de la PazMaria Corazon A De UngriaFrederick C DelfinJuli EdoSuthat FuchareonHo GhangTakashi GojoboriJunsong HanSheng-Feng HoBoon Peng HohWei HuangHidetoshi InokoPankaj JhaTimothy A JinamLi JinJongsun JungDaoroong KangwanpongJatupol KampuansaiGiulia C KennedyPreeti KhuranaHyung-Lae KimKwangjoong KimSangsoo KimWoo-Yeon KimKuchan KimmRyosuke KimuraTomohiro KoikeSupasak KulawonganunchaiVikrant KumarPoh San LaiJong-Young LeeSunghoon LeeEdison T LiuPartha P MajumderKiran Kumar MandapatiSangkot MarzukiWayne MitchellMitali MukerjiKenji NaritomiChumpol NgamphiwNorio NiikawaNao NishidaBermseok OhSangho OhJun OhashiAkira OkaRick OngCarmencita D PadillaPrasit PalittapongarnpimHenry B PerdigonMaude Elvira PhippsEileen PngYoshiyuki SakakiJazelyn M SalvadorYuliana SandralingVinod ScariaMark SeielstadMohd Ros SidekAmit SinhaMetawee SrikummoolHerawati SudoyoSumio SuganoHelena SuryadiYoshiyuki SuzukiKristina A TabbadaAdrian TanKatsushi TokunagaSissades TongsimaLilian P VillamorEric WangYing WangHaifeng WangJer-Yuarn WuHuasheng XiaoShuhua XuJin Ok YangYin Yao ShugartHyang-Sook YooWentao YuanGuoping ZhaoBin Alwi ZilfalilIndian Genome Variation Consortium

Mapping Human Genetic Diversity in Asia

HUGO Pan-Asian SNP Consortium et al. Science.

Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

Comment in

Similar articles

See all similar articles

Cited by 194 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback