Diagnosis of cirrhotic portal hypertension and compensatory circulation using transsplenic portal scintigraphy with (99m)Tc-phytate

J Nucl Med. 2010 Jan;51(1):52-6. doi: 10.2967/jnumed.109.067983. Epub 2009 Dec 15.

Abstract

Our objective was to investigate the diagnostic value and clinical significance of transsplenic portal scintigraphy in cirrhotic portal hypertension and compensatory circulation.

Methods: Transsplenic portal scintigraphy, ultrasound, and gastroscopy were performed on 50 patients with cirrhotic portal hypertension and on 10 controls. According to the Child-Pugh classification, 15 patients with cirrhosis were Child A, 19 were Child B, and 16 were Child C.

Results: In the control group, the splenoportal vein was shaped like the letter S, and the portosystemic shunt index was 0.19 +/- 0.07. Portal hypertension portosystemic shunts were of 3 types: intrahepatic (13 patients; index, 0.52 +/- 0.19), compensatory (31 patients; index, 0.64 +/- 0.28); and completely extrahepatic (6 patients; index, 0.91 +/- 0.03). Collateral vessels were uphill, downhill, or complex. The portosystemic shunt index increased as cirrhosis and esophageal varices increased. There was statistical significance among groups (P < 0.05 or < 0.01).

Conclusion: Transsplenic portal scintigraphy was sensitive for detecting the number and location of shunts and will allow for improved surgical planning.

MeSH terms

  • Aged
  • Collateral Circulation
  • Female
  • Humans
  • Hypertension, Portal / diagnostic imaging*
  • Hypertension, Portal / physiopathology*
  • Image Processing, Computer-Assisted
  • Ligation
  • Liver Cirrhosis / diagnostic imaging*
  • Liver Cirrhosis / physiopathology*
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Phytic Acid*
  • Portal Vein / diagnostic imaging
  • Portasystemic Shunt, Surgical
  • Radiopharmaceuticals*
  • Spleen / diagnostic imaging*
  • Splenic Vein / diagnostic imaging
  • Splenic Vein / surgery
  • Tomography, Emission-Computed, Single-Photon
  • Ultrasonography

Substances

  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium phytate
  • Phytic Acid