Ovarian granulosa-stromal cell tumors are characterized by trisomy 12

Am J Pathol. 1991 Mar;138(3):515-20.


Eleven ovarian granulosa-stromal cell tumors including 1 thecoma, 2 fibromas, 6 fibrothecomas, and 2 granulosa cell tumors, were karyotyped after direct harvest and/or short-term tissue culture. Bilateral fibrothecomas from one patient appeared to lack cytogenetic aberrations: the remaining nine tumors were characterized by trisomy for chromosome 12. Cytogenetic aberrations in the two granulosa cell tumors were much less complex than those described previously in undifferentiated carcinomas; accordingly cytogenetic analyses might be useful in distinguishing these categories. The consistent occurrence of trisomy 12 in different varieties of granulosa-stromal cell tumors suggests a common mechanism of oncogenesis within this diverse group of neoplasms. That mechanism probably involves promotion of low-grade, orderly cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 12*
  • DNA / genetics
  • Female
  • Flow Cytometry
  • Granulosa Cell Tumor / genetics*
  • Granulosa Cell Tumor / pathology
  • Humans
  • Karyotyping
  • Metaphase
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Ploidies
  • Trisomy*


  • DNA