Development of intrapancreatic transplantable model of pancreatic duct adenocarcinoma in Syrian golden hamsters

Am J Pathol. 1991 Mar;138(3):557-61.


Intrapancreatic and subcutaneous (SC) inoculation of cultured pancreatic cancer cells, derived from an induced primary pancreatic cancer in a Syrian hamster, resulted in tumor take in all recipient hamsters. The intrapancreatic allografts grew rapidly, were invasive, and metastasized into the lymph nodes and liver in 2 of 9 cases. In comparison, SC tumors grew relatively slower and formed a large encapsulated mass without invasion and metastases. Histologically, tumors of both sites showed fairly well-differentiated adenocarcinomas of ductal/ductular type resembling the induced primary cancer. Similar to the primary induced pancreatic cancers, tumor cells of both allografts expressed blood-group-related antigens, including A, B, H, Le(b), Le(y), Le(x), and tumor-associated antigen TAG-72. The tumor cells did not express Le(a), CA 19-9, 17-1A, or DU-PAN-2. The expression of these antigens was retained in the metastases and presented the same patterns of reactivity as the allografts. Thus intrapancreatic transplantation provides a rapid model for production of pancreatic cancer with morphologic similarities to human pancreatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / immunology
  • Adenocarcinoma / pathology*
  • Animals
  • Antigens, Neoplasm / analysis
  • Cricetinae
  • Immunohistochemistry
  • Mesocricetus
  • Neoplasm Transplantation*
  • Pancreatic Ducts*
  • Pancreatic Neoplasms / immunology
  • Pancreatic Neoplasms / pathology*
  • Tumor Cells, Cultured / transplantation


  • Antigens, Neoplasm