Axon-glial interactions at the Drosophila CNS midline

Cell Adh Migr. Jan-Mar 2010;4(1):67-71. doi: 10.4161/cam.4.1.10208. Epub 2010 Jan 29.


The glia that reside at the midline of the Drosophila CNS are an important embryonic signaling center and also wrap the axons that cross the CNS. The development of the midline glia (MG) is characterized by migration, ensheathment, subdivision of axon commissures, apoptosis, and the extension of glial processes. All of these events are characterized by cell-cell contact between MG and adjacent neurons. Cell adhesion and signaling proteins that mediate different aspects of MG development and MG-neuron interactions have been identified. This provides a foundation for ultimately obtaining an integrated picture of how the MG assemble into a characteristic axonal support structure in the CNS.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Axons / metabolism*
  • Cell Adhesion
  • Cell Communication*
  • Cell Movement
  • Central Nervous System / cytology*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / cytology*
  • Neuroglia / cytology*
  • Signal Transduction
  • Vertebrates


  • Drosophila Proteins