Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV-tuberculosis patients

AIDS. 2010 Jan 16;24(2):323-5. doi: 10.1097/QAD.0b013e328334895e.


Interferon gamma (IFNgamma)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNgamma and IFNgamma-inducible protein-10 levels in culture of whole blood samples from HIV-TB patients. We report that IFNgamma-inducible protein-10 detects a greater number of HIV-TB cases than IFNgamma and suggest that IFNgamma-inducible protein-10 may be a better alternative marker for latent TB infection diagnosis among immunocompromised individuals.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis*
  • AIDS-Related Opportunistic Infections / immunology
  • Biomarkers / metabolism
  • Chemokine CXCL10 / metabolism*
  • Humans
  • Interferon-gamma / metabolism*
  • Tuberculosis / diagnosis*
  • Tuberculosis / immunology


  • Biomarkers
  • Chemokine CXCL10
  • Interferon-gamma