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. 2010 Jan 19;102(2):369-75.
doi: 10.1038/sj.bjc.6605488. Epub 2009 Dec 15.

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer

H Nalwoga  1 , J B Arnes, H Wabinga, L A Akslen
Affiliations

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer

H Nalwoga et al. Br J Cancer. .

Abstract

Background: Putative breast cancer stem cells might express surface markers such as aldehyde dehydrogenase 1 (ALDH1) and BMI-1 proteins. The aim of this study was to explore the expression of these proteins in breast cancers from an African population and their associations with the basal-like phenotype (BLP) and other molecular characteristics.

Methods: We analysed 192 paraffin-embedded breast carcinoma samples by tissue microarrays and immunohistochemical methods.

Results: In total, 88 tumours (48%) expressed ALDH1, whereas 46 (25%) expressed BMI-1 protein. Expression of ALDH1 was associated with high histological grade (P<0.0005), high mitotic count (P<0.0005), high nuclear grade (P<0.0005), oestrogen receptor (ER) negativity (P<0.0005), progesterone receptor (PR) negativity (P=0.009), p53 expression (P=0.034), cytokeratin 5/6 positivity (P=0.008), epidermal growth factor receptor (EGFR) expression (P=0.015) and the BLP (P<0.0005), whereas it was inversely associated with BMI-1 staining (P=0.009). On the other hand, BMI-1 expression was associated with low histological grade (P=0.004) and ER positivity (P=0.001).

Conclusion: There was a high prevalence of ALDH1 expression among breast carcinomas and associations with basal markers and features of aggressive tumours. Studies are required to elucidate the importance of these findings for improved understanding of breast cancer biology.

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Figures

Figure 1
Figure 1
Positive (A) and negative (B) expression of aldehyde dehydrogenase 1 (ALDH1) protein in tumour cells of breast carcinomas (both × 400 magnification).
See this image and copyright information in PMC

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References

    1. Abraham BK, Fritz P, McClellan M, Hauptvogel P, Athelogou M, Brauch H (2005) Prevalence of CD44+/CD24−/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res 11: 1154–1159 - PubMed
    1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumourigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983–3988 - PMC - PubMed
    1. Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M (1993) Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum Mol Genet 2: 1597–1603 - PubMed
    1. Arnes JB, Collett K, Akslen LA (2008) Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1. Histopathology 52: 370–380 - PubMed
    1. Bachmann IM, Puntervoll HE, Otte AP, Akslen LA (2008) Loss of BMI-1 expression is associated with clinical progress of malignant melanoma. Mod Pathol 21: 583–590 - PubMed

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