Physiological and oncogenic Aurora-A pathway

Int J Biol Sci. 2009 Nov 26;5(7):758-62. doi: 10.7150/ijbs.5.758.

Abstract

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.

Keywords: Aurora-A; Cell Cycle; Checkpoint; Genome Instability; Phosphorylation; Plk1; mTOR.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aurora Kinases
  • BRCA1 Protein / metabolism
  • Cell Cycle Proteins / metabolism
  • Cell Transformation, Neoplastic*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Neoplasms / enzymology*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Protein Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Signal Transduction
  • TOR Serine-Threonine Kinases

Substances

  • BRCA1 Protein
  • Cell Cycle Proteins
  • Intracellular Signaling Peptides and Proteins
  • Proto-Oncogene Proteins
  • MTOR protein, human
  • Aurora Kinases
  • Protein Serine-Threonine Kinases
  • TOR Serine-Threonine Kinases
  • polo-like kinase 1