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, 21 (4), 501-11

Determinants of Serum 25 Hydroxyvitamin D Levels in a Nationwide Cohort of Blacks and non-Hispanic Whites

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Determinants of Serum 25 Hydroxyvitamin D Levels in a Nationwide Cohort of Blacks and non-Hispanic Whites

Jacqueline Chan et al. Cancer Causes Control.

Abstract

Objective: To develop algorithms predicting serum 25 hydroxyvitamin D [s25(OH)D] for a large epidemiological study whose subjects come from large geographic areas, are racially diverse and have a wide range in age, skin types, and month of blood sample collection. This will allow a regression calibration approach to determine s25(OH)D levels replacing the more costly method of collection and analysis of blood samples.

Study design and setting: Questionnaire data from a subsample of 236 non-Hispanic whites (whites) and 209 blacks from the widely dispersed Adventist Health Study-2 (n = 96,000) were used to develop prediction algorithms for races separately and combined. A single blood sample was collected from each subject, at different times throughout the year.

Results: Models with independent variables age, sex, BMI, skin type, UV season, erythemal zone, total dietary vitamin D intake, and sun exposure factor explained 22 and 31% of the variance of s25(OH)D levels in white and black populations, respectively (42% when combined). UV season and erythemal zone determined from measured UV radiation produced models with higher R (2) than season and latitude.

Conclusion: Combining races with a term for race and using variables with measured UV radiation capture the variance in s25(OH)D levels better than analyzing races separately.

Figures

Fig. 1
Fig. 1
Monthly change in serum 25 hydroxyvitamin D levels using deviations from multivariate-adjusted annual means. Black square non-Hispanic whites, Black up pointing triangle blacks, - -..- -.. No samples Collected

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