Abstract
The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.
(c) 2009 Wiley-Liss, Inc.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Amino Acid Sequence
-
Biotechnology / trends*
-
Cystine Knot Motifs / genetics
-
Cystine Knot Motifs / physiology*
-
LDL-Receptor Related Proteins / chemistry*
-
LDL-Receptor Related Proteins / classification
-
LDL-Receptor Related Proteins / metabolism
-
Ligands
-
Models, Molecular*
-
Molecular Sequence Data
-
Proteomics
-
Signal Transduction / physiology*
-
Wnt Proteins / metabolism*
Substances
-
LDL-Receptor Related Proteins
-
Ligands
-
Wnt Proteins