Wnt modulators in the biotech pipeline

Dev Dyn. 2010 Jan;239(1):102-14. doi: 10.1002/dvdy.22181.


The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Biotechnology / trends*
  • Cystine Knot Motifs / genetics
  • Cystine Knot Motifs / physiology*
  • LDL-Receptor Related Proteins / chemistry*
  • LDL-Receptor Related Proteins / classification
  • LDL-Receptor Related Proteins / metabolism
  • Ligands
  • Models, Molecular*
  • Molecular Sequence Data
  • Proteomics
  • Signal Transduction / physiology*
  • Wnt Proteins / metabolism*


  • LDL-Receptor Related Proteins
  • Ligands
  • Wnt Proteins