Alveolar ridge augmentation in irradiated rabbit mandibles

J Biomed Mater Res A. 2010 Jun 15;93(4):1519-26. doi: 10.1002/jbm.a.32644.


Oral carcinomas are frequently treated with a nonsegmental mandibulectomy plus radiotherapy. Improving the quality of life of these patients depends on the possibilities for dental rehabilitation. The aim of this study was to increase the alveolar ridge height. Twelve white New Zealand rabbits underwent surgery to produce a 11 x 9 x 7 mm(3) horizontal bicortical full-thickness defect at the alveolar ridge of the left mandible. Six were implanted with a composite associating resorbable collagen membrane filled with micro-macroporous biphasic calcium phosphate granules. After a daily radiation delivery schedule for 4 weeks, a total autologous bone marrow graft was injected percutaneously into the center of the implant. All animals were sacrificed at 16 weeks. Successful osseous colonization was observed in all implants. Significant ridge augmentation was observed (p = 0.0349) in the implanted group compared with the control group. This study contributed to producing an experimental model for oncological mandible defects in rabbits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials
  • Bone Marrow / pathology
  • Bone Marrow Transplantation / methods*
  • Calcium Phosphates / chemistry*
  • Carcinoma / pathology*
  • Carcinoma / therapy*
  • Cell Lineage
  • Ceramics / chemistry
  • Mandible / pathology*
  • Microscopy, Electron, Scanning / methods
  • Mouth Neoplasms / pathology*
  • Mouth Neoplasms / therapy*
  • Rabbits
  • Radiotherapy / methods
  • X-Ray Microtomography / methods


  • Biocompatible Materials
  • Calcium Phosphates
  • calcium phosphate