Mechanisms maintaining peripheral tolerance

Nat Immunol. 2010 Jan;11(1):21-7. doi: 10.1038/ni.1817. Epub 2009 Dec 17.


The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Apoptosis / immunology
  • Dendritic Cells / immunology*
  • Humans
  • Immune Tolerance / immunology*
  • Major Histocompatibility Complex / immunology*
  • Models, Immunological
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / immunology*


  • Receptors, Antigen, T-Cell