Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA

Nutr Res Pract. 2008 Winter;2(4):326-30. doi: 10.4162/nrp.2008.2.4.326. Epub 2008 Dec 31.


Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.

Keywords: 9E,11E-CLA; Conjugated linoleic acid (CLA); anti-inflammatory; isomer-specificity.