Latent herpes simplex virus infections in sensory ganglia of mice after topical treatment with adenine arabinoside and adenine arabinoside monophosphate

Antimicrob Agents Chemother. 1977 Nov;12(5):577-81. doi: 10.1128/AAC.12.5.577.


Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred only a partial protection against the establishment of latent HSV infection in the spinal root ganglia of the treated animals. The immune response, as judged from levels of HSV-specific neutralizing serum antibody titers, was not impaired by the antiviral treatment.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Animals
  • Antibodies / analysis
  • Central Nervous System Diseases / prevention & control*
  • Ganglia, Spinal*
  • Herpesviridae Infections / drug therapy*
  • Herpesviridae Infections / immunology
  • Mice
  • Ointments
  • Simplexvirus / drug effects
  • Skin Diseases, Infectious / drug therapy*
  • Vidarabine / administration & dosage*
  • Vidarabine / therapeutic use


  • Antibodies
  • Ointments
  • Vidarabine