[Effects of thapsigargicin on Ca2+ movements in L1210 cells permeabilized with digitonin]
- PMID: 20017396
[Effects of thapsigargicin on Ca2+ movements in L1210 cells permeabilized with digitonin]
Abstract
The effect of Thapsigargicin (TGC), a non-phorbol ester type tumor promoter, on Ca2+ movements has been investigated using L1210 mouse lymphoma cells. Ca2+ release from intact and digitonin permeabilized cells was evaluated using Fura-2 and Fura-3. TGC like Thapsigargin (TG) has the ability to discharge the intracellular Ca2+ stores and to increase intracellular free Ca2+ concentrations. TGC in a concentration dependent manner (0.16-16 nM) also inhibited cell growth and this effect was at least partially reversed by arachidonate.
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