Promoter architecture and the evolvability of gene expression

J Biol. 2009;8(11):95. doi: 10.1186/jbiol204. Epub 2009 Dec 14.


Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Gene Expression Regulation*
  • Humans
  • Phenotype
  • Promoter Regions, Genetic / genetics*
  • TATA Box / genetics