L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity

F VanMiddlesworth; M N Omstead; D Schmatz; K Bartizal; R Fromtling; G Bills; K Nollstadt; S Honeycutt; M Zweerink; G Garrity

doi:10.7164/antibiotics.44.45

L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity

J Antibiot (Tokyo). 1991 Jan;44(1):45-51. doi: 10.7164/antibiotics.44.45.

Authors

F VanMiddlesworth¹, M N Omstead, D Schmatz, K Bartizal, R Fromtling, G Bills, K Nollstadt, S Honeycutt, M Zweerink, G Garrity, et al.

Affiliation

¹ Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065.

PMID: 2001985
DOI: 10.7164/antibiotics.44.45

Abstract

A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

MeSH terms

Animals
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use
Candida / drug effects
Candidiasis / drug therapy
Cryptococcus neoformans / drug effects
Disease Models, Animal
Fermentation
Fungi / drug effects*
Glucans / antagonists & inhibitors*
Glucans / biosynthesis
Male
Mice
Mitosporic Fungi / classification
Mitosporic Fungi / metabolism
Pneumonia, Pneumocystis / drug therapy*
Pyrans / isolation & purification
Pyrans / pharmacology*
Pyrans / therapeutic use
Rats
Rats, Inbred Strains
beta-Glucans*

Substances

Antifungal Agents
Glucans
Pyrans
beta-Glucans
L 687781
beta-1,3-glucan