L-687,781, a New Member of the Papulacandin Family of beta-1,3-D-glucan Synthesis Inhibitors. I. Fermentation, Isolation, and Biological Activity

J Antibiot (Tokyo). 1991 Jan;44(1):45-51. doi: 10.7164/antibiotics.44.45.

Abstract

A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

MeSH terms

  • Animals
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Candida / drug effects
  • Candidiasis / drug therapy
  • Cryptococcus neoformans / drug effects
  • Disease Models, Animal
  • Fermentation
  • Fungi / drug effects*
  • Glucans / antagonists & inhibitors*
  • Glucans / biosynthesis
  • Male
  • Mice
  • Mitosporic Fungi / classification
  • Mitosporic Fungi / metabolism
  • Pneumonia, Pneumocystis / drug therapy*
  • Pyrans / isolation & purification
  • Pyrans / pharmacology*
  • Pyrans / therapeutic use
  • Rats
  • Rats, Inbred Strains
  • beta-Glucans*

Substances

  • Antifungal Agents
  • Glucans
  • Pyrans
  • beta-Glucans
  • L 687781
  • beta-1,3-glucan