The insulin-like growth factor-1 axis and its potential as a therapeutic target in central nervous system (CNS) disorders

Cent Nerv Syst Agents Med Chem. 2009 Jun;9(2):95-109. doi: 10.2174/187152409788452108.

Abstract

The insulin-like growth factor-1 (IGF-1) is a pleiotropic factor. Many studies have revealed its importance in the development and maintenance of the central nervous system (CNS). This review will discuss the IGF-1 axis, from the factor itself to the signalling pathways it activates, and its tight regulation. Particular focus will be brought on potential therapeutic targets of the IGF-1 axis in CNS disorders, including brain tumours and neurodegenerative diseases affecting neurons and oligodendrocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Autistic Disorder / immunology
  • Brain / metabolism
  • Brain / pathology
  • Brain Neoplasms / metabolism
  • Cell Differentiation / physiology
  • Central Nervous System / physiopathology*
  • Central Nervous System Diseases / complications
  • Central Nervous System Diseases / genetics
  • Central Nervous System Diseases / pathology
  • Cognition / physiology
  • Deer
  • Genetic Therapy
  • Genomic Imprinting*
  • Human Growth Hormone / physiology
  • Insulin-Like Growth Factor I / physiology*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Nerve Regeneration / immunology*
  • Nerve Regeneration / physiology*
  • Neuronal Plasticity / physiology
  • Oligodendroglia
  • Signal Transduction

Substances

  • Human Growth Hormone
  • Insulin-Like Growth Factor I