Abstract
The insulin-like growth factor-1 (IGF-1) is a pleiotropic factor. Many studies have revealed its importance in the development and maintenance of the central nervous system (CNS). This review will discuss the IGF-1 axis, from the factor itself to the signalling pathways it activates, and its tight regulation. Particular focus will be brought on potential therapeutic targets of the IGF-1 axis in CNS disorders, including brain tumours and neurodegenerative diseases affecting neurons and oligodendrocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / physiology
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Animals
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Autistic Disorder / immunology
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Brain / metabolism
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Brain / pathology
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Brain Neoplasms / metabolism
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Cell Differentiation / physiology
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Central Nervous System / physiopathology*
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Central Nervous System Diseases / complications
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Central Nervous System Diseases / genetics
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Central Nervous System Diseases / pathology
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Cognition / physiology
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Deer
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Genetic Therapy
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Genomic Imprinting*
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Human Growth Hormone / physiology
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Insulin-Like Growth Factor I / physiology*
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Mice
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Mice, Knockout
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Mice, Transgenic
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Nerve Regeneration / immunology*
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Nerve Regeneration / physiology*
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Neuronal Plasticity / physiology
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Oligodendroglia
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Signal Transduction
Substances
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Human Growth Hormone
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Insulin-Like Growth Factor I