Long-term antimicrobial therapy in the prevention of recurrent soft-tissue infections

J Infect. 1991 Jan;22(1):37-40. doi: 10.1016/0163-4453(91)90898-3.


Thirty-six patients who had suffered two or more episodes of erysipelas or cellulitis during the previous year were randomly divided into two equal groups; one group received erythromycin base 250 mg b.i.d. for 18 months, while the other group received no prophylaxis for a similar period. No patients in the treated group developed infection during the 18 months' follow-up but eight of the control group (50%) relapsed and required antibiotic treatment. Prolonged antimicrobial prophylaxis is effective and safe in preventing recurrent episodes of soft-tissue infections.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Cellulitis / prevention & control*
  • Drug Administration Schedule
  • Erysipelas / prevention & control*
  • Erythromycin / therapeutic use*
  • Humans
  • Recurrence


  • Erythromycin