Liver impairment after concomitant administration of bosentan and clarithromycin in systemic sclerosis

Joint Bone Spine. 2010 Jan;77(1):81-2. doi: 10.1016/j.jbspin.2009.04.010. Epub 2009 Dec 22.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Antihypertensive Agents / adverse effects*
  • Bosentan
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / metabolism
  • Clarithromycin / adverse effects*
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Fingers / pathology
  • Humans
  • Hypertension, Pulmonary / drug therapy
  • Hypertension, Pulmonary / etiology
  • Liver Function Tests
  • Middle Aged
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / drug therapy*
  • Skin Ulcer / etiology
  • Skin Ulcer / prevention & control
  • Sulfonamides / adverse effects*

Substances

  • Anti-Bacterial Agents
  • Antihypertensive Agents
  • Sulfonamides
  • Clarithromycin
  • Bosentan