Abstract
In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Substitution
-
Fluorescent Dyes / chemistry*
-
Insulin-Like Growth Factor Binding Protein 2 / chemistry*
-
Magnetic Resonance Spectroscopy
-
Microscopy, Fluorescence
-
Mutagenesis, Site-Directed
-
Nanotubes / chemistry*
-
Protein Folding
Substances
-
Fluorescent Dyes
-
Insulin-Like Growth Factor Binding Protein 2