Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Dec 16;9:1476-97.
doi: 10.1100/tsw.2009.158.

Molecular Biology of Rotavirus Entry and Replication

Affiliations
Free PMC article
Review

Molecular Biology of Rotavirus Entry and Replication

Marie Christine Ruiz et al. ScientificWorldJournal. .
Free PMC article

Abstract

Rotavirus is a nonenveloped, double-stranded, RNA virus belonging to the Reoviridae family and is the major etiological agent of viral gastroenteritis in young children and young animals. Remarkable progress in the understanding of the rotavirus cycle has been made in the last 10 years. The knowledge of viral replication thus far acquired is based on structural studies, the expression and coexpression of individual viral proteins, silencing of individual genes by siRNAs, and the effects that these manipulations have on the physiology of the infected cell. The functions of the individual rotavirus proteins have been largely dissected; however, the interactions between them and with cell proteins, and the molecular mechanisms of virus replication, are just beginning to be understood. These advancements represent the basis for the development of effective vaccination and rational therapeutic strategies to combat rotavirus infection and diarrhea syndromes. In this paper, we review and try to integrate the new knowledge about rotavirus entry, replication, and assembly, and pose some of the questions that remain to be solved.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

Publication types

Substances

Feedback